O1.2.3 Long-acting bronchodilator combinations
A Cochrane systematic review of five studies found that the combination of tiotropium and a long-acting beta-agonist provided small improvements in health-related quality of life (mean difference in total SGRQ of -1.61, 95% CI -2.93 to -0.29 over 6 to 12 months) and bronchodilation (mean difference in pre-bronchodilator FEV1 0.07 L; 95% CI 0.05 to 0.09), compared to tiotropium alone (Karner and Cates, 2012) [evidence level I]. It should be noted that the majority of participants in these studies had severe COPD. The clinical importance of these small benefits was uncertain. No statistically significant differences in mortality or hospital admissions were found.
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COPD-X Plan - Version 2.34 - November 2012