SAJKOV, D., MCEVOY, R. D., COWIE, R. J., BRADLEY, J. A., ANTIC, R., MORRIS, R. G. & FRITH, P. A. (1993) Felodipine improves pulmonary hemodynamics in chronic obstructive pulmonary disease. Chest, 103, 1354-61.

SAJKOV, D., WANG, T., FRITH, P. A., BUNE, A. J., ALPERS, J. A. & MCEVOY, R. D. (1997) A comparison of two long-acting vasoselective calcium antagonists in pulmonary hypertension secondary to COPD. Chest, 111, 1622-30.

SALPETER, S., ORMISTON, T. & SALPETER, E. (2005) Cardioselective beta-blockers for chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD003566.

SALPETER, S. R., BUCKLEY, N. S. & SALPETER, E. E. (2006) Meta-analysis: anticholinergics, but not beta-agonists, reduce severe exacerbations and respiratory mortality in COPD. J Gen Intern Med, 21, 1011-9.

SAMBROOK, P. N., SEEMAN, E., PHILLIPS, S. R. & EBELING, P. R. (2002) Preventing osteoporosis: outcomes of the Australian Fracture Prevention Summit. Med J Aust, 176 Suppl, S1-16.

SANTO TOMAS, L. H. (2011) Emphysema and chronic obstructive pulmonary disease in coal miners. Curr Opin Pulm Med, 17, 123-5.

SCHANE, R. E., WALTER, L. C., DINNO, A., COVINSKY, K. E. & WOODRUFF, P. G. (2008) Prevalence and risk factors for depressive symptoms in persons with chronic obstructive pulmonary disease. J Gen Intern Med, 23, 1757-62.

SCHARF, S. M., IQBAL, M., KELLER, C., CRINER, G., LEE, S. & FESSLER, H. E. (2002) Hemodynamic characterization of patients with severe emphysema. Am J Respir Crit Care Med, 166, 314-22.

SCHOLS, A. M., SLANGEN, J., VOLOVICS, L. & WOUTERS, E. F. (1998) Weight loss is a reversible factor in the prognosis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 157, 1791-7.

SCHWARTZ, J. L. (1987) Review and Evaluation of Smoking Cessation Methods: The United States and Canada, 1978-1985 (NIH Publication No.87-2940). Bethesda, MD., National Cancer Institute, National Institutes of Health.

SEEMUNGAL, T., HARPER-OWEN, R., BHOWMIK, A., MORIC, I., SANDERSON, G., MESSAGE, S., MACCALLUM, P., MEADE, T. W., JEFFRIES, D. J., JOHNSTON, S. L. & WEDZICHA, J. A. (2001) Respiratory viruses, symptoms, and inflammatory markers in acute exacerbations and stable chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 164, 1618-23.

SEEMUNGAL, T. A., WILKINSON, T. M., HURST, J. R., PERERA, W. R., SAPSFORD, R. J. & WEDZICHA, J. A. (2008) Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med, 178, 1139-47.

SELROOS, O., BORGSTROM, L. & INGELF, J. (2009) Use of dry powder inhalers in acute exacerbations of asthma and COPD. Ther Adv Respir Dis, 3, 81-91.

SENDEROVITZ, T., VESTBO, J., FRANDSEN, J., MALTBAEK, N., NORGAARD, M., NIELSEN, C. & KAMPMANN, J. P. (1999) Steroid reversibility test followed by inhaled budesonide or placebo in outpatients with stable chronic obstructive pulmonary disease. The Danish Society of Respiratory Medicine. Respir Med, 93, 715-8.

SERGINSON, J. G., YANG, I. A., ARMSTRONG, J. G., COOPER, D. M., MATTHIESSON, A. M., MORRISON, S. C., GAIR, J. M., COOPER, B. & ZIMMERMAN, P. V. (2009) Variability in the rate of prescription and cost of domiciliary oxygen therapy in Australia. Med J Aust, 191, 549-53.

SHANMUGAM, G., BHUTANI, S., KHAN, D. A. & BROWN, E. S. (2007) Psychiatric considerations in pulmonary disease. Psychiatr Clin North Am, 30, 761-80.

SHEPPERD, S., HARWOOD, D., JENKINSON, C., GRAY, A., VESSEY, M. & MORGAN, P. (1998) Randomised controlled trial comparing hospital at home care with inpatient hospital care. I: three month follow up of health outcomes. BMJ, 316, 1786-91.

SHIRTCLIFFE, P., MARSH, S., TRAVERS, J., WEATHERALL, M. & BEASLEY, R. (2012) Childhood asthma and GOLD-defined chronic obstructive pulmonary disease. Intern Med J, 42, 83-88.

SHIRTCLIFFE, P., WEATHERALL, M., MARSH, S., TRAVERS, J., HANSELL, A., MCNAUGHTON, A., ALDINGTON, S., MUELLEROVA, H. & BEASLEY, R. (2007) COPD prevalence in a random population survey: a matter of definition. European Respiratory Journal, 30, 232-239.

SHORT, P. M., LIPWORTH, S. I., ELDER, D. H., SCHEMBRI, S. & LIPWORTH, B. J. (2011) Effect of beta blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study. BMJ, 342, d2549.

SIAFAKAS NM & BOUROS D (1998) Management of acute exacerbation of chronic obstructive pulmonary disease. IN POSTMA, D. & SIAFAKAS NM (Eds.) Management of Chronic Obstructive Pulmonary Disease. Sheffield, ERS Monograph.

SIAFAKAS, N. M., VERMEIRE, P., PRIDE, N. B., PAOLETTI, P., GIBSON, J., HOWARD, P., YERNAULT, J. C., DECRAMER, M., HIGENBOTTAM, T., POSTMA, D. S. & ET AL. (1995) Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force. Eur Respir J, 8, 1398-420.

SIMBERKOFF, M. S., CROSS, A. P., AL-IBRAHIM, M., BALTCH, A. L., GEISELER, P. J., NADLER, J., RICHMOND, A. S., SMITH, R. P., SCHIFFMAN, G., SHEPARD, D. S. & ET AL. (1986) Efficacy of pneumococcal vaccine in high-risk patients. Results of a Veterans Administration Cooperative Study. N Engl J Med, 315, 1318-27.

SIMONNEAU, G., ROBBINS, I. M., BEGHETTI, M., CHANNICK, R. N., DELCROIX, M., DENTON, C. P., ELLIOTT, C. G., GAINE, S. P., GLADWIN, M. T., JING, Z. C., KROWKA, M. J., LANGLEBEN, D., NAKANISHI, N. & SOUZA, R. (2009) Updated clinical classification of pulmonary hypertension. J Am Coll Cardiol, 54, S43-54.

SIN, D. D., BELL, N. R., SVENSON, L. W. & MAN, S. F. (2002) The impact of follow-up physician visits on emergency readmissions for patients with asthma and chronic obstructive pulmonary disease: a population-based study. Am J Med, 112, 120-5.

SINGH, S., AMIN, A. V. & LOKE, Y. K. (2009) Long-term use of inhaled corticosteroids and the risk of pneumonia in chronic obstructive pulmonary disease: a meta-analysis. Arch Intern Med, 169, 219-29.

SINGH, S., LOKE, Y. K. & FURBERG, C. D. (2008) Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. Jama, 300, 1439-50.

SKWARSKA, E., COHEN, G., SKWARSKI, K. M., LAMB, C., BUSHELL, D., PARKER, S. & MACNEE, W. (2000) Randomized controlled trial of supported discharge in patients with exacerbations of chronic obstructive pulmonary disease. Thorax, 55, 907-12.

SLATORE, C. G., BRYSON, C. L. & AU, D. H. (2009) The association of inhaled corticosteroid use with serum glucose concentration in a large cohort. Am J Med, 122, 472-8.

SMITH, C. B., KANNER, R. E., GOLDEN, C. A., KLAUBER, M. R. & RENZETTI, A. D., JR. (1980) Effect of viral infections on pulmonary function in patients with chronic obstructive pulmonary diseases. J Infect Dis, 141, 271-80.

SMOLLER, J. W., POLLACK, M. H., OTTO, M. W., ROSENBAUM, J. F. & KRADIN, R. L. (1996) Panic anxiety, dyspnea, and respiratory disease. Theoretical and clinical considerations. Am J Respir Crit Care Med, 154, 6-17.

SOLER, N., TORRES, A., EWIG, S., GONZALEZ, J., CELIS, R., EL-EBIARY, M., HERNANDEZ, C. & RODRIGUEZ-ROISIN, R. (1998) Bronchial microbial patterns in severe exacerbations of chronic obstructive pulmonary disease (COPD) requiring mechanical ventilation. Am J Respir Crit Care Med, 157, 1498-505.

SOURK, R. L. & NUGENT, K. M. (1983) Bronchodilator testing: confidence intervals derived from placebo inhalations. Am Rev Respir Dis, 128, 153-7.

SPENCER, S., KARNER, C., CATES, C. J. & EVANS, D. J. (2011) Inhaled corticosteroids versus long-acting beta(2)-agonists for chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD007033.

SPRENKLE, M. D., NIEWOEHNER, D. E., MACDONALD, R., RUTKS, I. & WILT, T. J. (2004) Clinical Efficacy of OM-85 BV in COPD and Chronic Bronchitis: A Systematic Review. COPD: Journal of Chronic Obstructive Pulmonary Disease, 2, 167 - 175.

STAPLETON, R. D., NIELSEN, E. L., ENGELBERG, R. A., PATRICK, D. L. & CURTIS, J. R. (2005) Association of depression and life-sustaining treatment preferences in patients with COPD. Chest, 127, 328-34.

STEAD, L. F., PERERA, R., BULLEN, C., MANT, D. & LANCASTER, T. (2008) Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev, CD000146.

STEPHENSON, A., SEITZ, D., BELL, C. M., GRUNEIR, A., GERSHON, A. S., AUSTIN, P. C., FU, L., ANDERSON, G. M., ROCHON, P. A. & GILL, S. S. (2011) Inhaled anticholinergic drug therapy and the risk of acute urinary retention in chronic obstructive pulmonary disease: a population-based study. Arch Intern Med, 171, 914-20.

STOCKLEY, R. A., O'BRIEN, C., PYE, A. & HILL, S. L. (2000) Relationship of sputum color to nature and outpatient management of acute exacerbations of COPD. Chest, 117, 1638-45.

STOLZ, D., RASCH, H., LINKA, A., DI VALENTINO, M., MEYER, A., BRUTSCHE, M. & TAMM, M. (2008) A randomised, controlled trial of bosentan in severe COPD. Eur Respir J, 32, 619-28.

STRASSMANN, R., BAUSCH, B., SPAAR, A., KLEIJNEN, J., BRAENDLI, O. & PUHAN, M. A. (2009) Smoking cessation interventions in COPD: a network meta-analysis of randomised trials. Eur Respir J, 34, 634-40.

SUISSA, S. (2008) Lung function decline in COPD trials: bias from regression to the mean. Eur Respir J, 32, 829-31.

SUISSA, S. & BARNES, P. J. (2009) Inhaled corticosteroids in COPD: the case against. Eur Respir J, 34, 13-6.

TABAK, Y. P., SUN, X., JOHANNES, R. S., GUPTA, V. & SHORR, A. F. (2009) Mortality and need for mechanical ventilation in acute exacerbations of chronic obstructive pulmonary disease: development and validation of a simple risk score. Arch Intern Med, 169, 1595-602.

TANDON, M. K., PHILLIPS, M., WATERER, G., DUNKLEY, M., COMANS, P. & CLANCY, R. (2010) Oral immunotherapy with inactivated nontypeable Haemophilus influenzae reduces severity of acute exacerbations in severe COPD. Chest, 137, 805-11.

TANG, C. Y., TAYLOR, N. F. & BLACKSTOCK, F. C. (2010) Chest physiotherapy for patients admitted to hospital with an acute exacerbation of chronic obstructive pulmonary disease (COPD): a systematic review. Physiotherapy, 96, 1-13.

TARPY, S. P. & CELLI, B. R. (1995) Long-term oxygen therapy. N Engl J Med, 333, 710-4.

TASHKIN, D. P., ALTOSE, M. D., CONNETT, J. E., KANNER, R. E., LEE, W. W. & WISE, R. A. (1996) Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am J Respir Crit Care Med, 153, 1802-11.

TASHKIN, D. P., CELLI, B., SENN, S., BURKHART, D., KESTEN, S., MENJOGE, S. & DECRAMER, M. (2008) A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med, 359, 1543-54.

TASHKIN, D. P., RENNARD, S., HAYS, J. T., MA, W., LAWRENCE, D. & LEE, T. C. (2011) Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trial. Chest, 139, 591-9.

TAYLOR, D. R., BUICK, B., KINNEY, C., LOWRY, R. C. & MCDEVITT, D. G. (1985) The efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstruction. Am Rev Respir Dis, 131, 747-51.

TAYLOR, S. J., CANDY, B., BRYAR, R. M., RAMSAY, J., VRIJHOEF, H. J., ESMOND, G., WEDZICHA, J. A. & GRIFFITHS, C. J. (2005) Effectiveness of innovations in nurse led chronic disease management for patients with chronic obstructive pulmonary disease: systematic review of evidence. BMJ, 331, 485.

TERADA, K., MURO, S., SATO, S., OHARA, T., HARUNA, A., MARUMO, S., KINOSE, D., OGAWA, E., HOSHINO, Y., NIIMI, A., TERADA, T. & MISHIMA, M. (2008) Impact of gastro-oesophageal reflux disease symptoms on COPD exacerbation. Thorax, 63, 951-5.

TERZANO, C., PETROIANNI, A., CONTI, V., CECCARELLI, D., GRAZIANI, E., SANDUZZI, A. & D'AVELLI, S. (2008) Rational timing of combination therapy with tiotropium and formoterol in moderate and severe COPD. Respir Med, 102, 1701-7.

THAON, I., THIEBAUT, A., JOCHAULT, L., LEFEBVRE, A., LAPLANTE, J. J. & DALPHIN, J. C. (2011) Influence of hay and animal feed exposure on respiratory status: a longitudinal study. Eur Respir J, 37, 767-74.

THE THORACIC SOCIETY OF AUSTRALIA AND NEW ZEALAND NEW ZEALAND BRANCH & ASTHMA AND RESPIRATORY FOUNDATION OF NEW ZEALAND (2003) The burden of COPD in New Zealand.

THERAPEUTIC GUIDELINES LIMITED (2000) Therapeutic Guidelines: Antibiotic, North Melbourne, Therapeutic Guidelines Limited.

THOMPSON, A. B., MUELLER, M. B., HEIRES, A. J., BOHLING, T. L., DAUGHTON, D., YANCEY, S. W., SYKES, R. S. & RENNARD, S. I. (1992) Aerosolized beclomethasone in chronic bronchitis. Improved pulmonary function and diminished airway inflammation. Am Rev Respir Dis, 146, 389-95.

TONNESEN, P., CARROZZI, L., FAGERSTROM, K. O., GRATZIOU, C., JIMENEZ-RUIZ, C., NARDINI, S., VIEGI, G., LAZZARO, C., CAMPELL, I. A., DAGLI, E. & WEST, R. (2007) Smoking cessation in patients with respiratory diseases: a high priority, integral component of therapy. Eur Respir J, 29, 390-417.

TONNESEN, P., MIKKELSEN, K. & BREMANN, L. (2006) Nurse-conducted smoking cessation in patients with COPD using nicotine sublingual tablets and behavioral support. Chest, 130, 334-42.

TRAPPENBURG, J. C., MONNINKHOF, E. M., BOURBEAU, J., TROOSTERS, T., SCHRIJVERS, A. J., VERHEIJ, T. J. & LAMMERS, J. W. (2011) Effect of an action plan with ongoing support by a case manager on exacerbation-related outcome in patients with COPD: a multicentre randomised controlled trial. Thorax, 66, 977-84.

TROOSTERS, T., CASABURI, R., GOSSELINK, R. & DECRAMER, M. (2005) Pulmonary rehabilitation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 172, 19-38.

TURNER, S. E., EASTWOOD, P. R., CECINS, N. M., HILLMAN, D. R. & JENKINS, S. C. (2004) Physiologic responses to incremental and self-paced exercise in COPD: a comparison of three tests. Chest, 126, 766-73.

UCHIDA, H., SUZUKI, T., MAMO, D. C., MULSANT, B. H., KIKUCHI, T., TAKEUCHI, H., TOMITA, M., WATANABE, K., YAGI, G. & KASHIMA, H. (2009) Benzodiazepine and antidepressant use in elderly patients with anxiety disorders: a survey of 796 outpatients in Japan. J Anxiety Disord, 23, 477-81.

US PUBLIC HEALTH SERVICE (2000) A clinical practice guideline for treating tobacco use and dependence: A US Public Health Service report. The Tobacco Use and Dependence Clinical Practice Guideline Panel, Staff, and Consortium Representatives. JAMA, 283, 3244-54.

VAN DER MEER, R. M., WAGENA, E. J., OSTELO, R. W., JACOBS, J. E. & VAN SCHAYCK, C. P. (2003) Smoking cessation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD002999.

VAN GESTEL, Y. R., HOEKS, S. E., SIN, D. D., STAM, H., MERTENS, F. W., BAX, J. J., VAN DOMBURG, R. T. & POLDERMANS, D. (2009) Beta-blockers and health-related quality of life in patients with peripheral arterial disease and COPD. Int J Chron Obstruct Pulmon Dis, 4, 177-83.

VAN GESTEL, Y. R., HOEKS, S. E., SIN, D. D., WELTEN, G. M., SCHOUTEN, O., WITTEVEEN, H. J., SIMSEK, C., STAM, H., MERTENS, F. W., BAX, J. J., VAN DOMBURG, R. T. & POLDERMANS, D. (2008) Impact of cardioselective beta-blockers on mortality in patients with chronic obstructive pulmonary disease and atherosclerosis. Am J Respir Crit Care Med, 178, 695-700.

VATHENEN, A. S., BRITTON, J. R., EBDEN, P., COOKSON, J. B., WHARRAD, H. J. & TATTERSFIELD, A. E. (1988) High-dose inhaled albuterol in severe chronic airflow limitation. Am Rev Respir Dis, 138, 850-5.

VESTBO, J., ANDERSON, J. A., CALVERLEY, P. M., CELLI, B., FERGUSON, G. T., JENKINS, C., KNOBIL, K., WILLITS, L. R., YATES, J. C. & JONES, P. W. (2009) Adherence to inhaled therapy, mortality and hospital admission in COPD. Thorax, 64, 939-43.

VESTBO, J., SORENSEN, T., LANGE, P., BRIX, A., TORRE, P. & VISKUM, K. (1999) Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial. Lancet, 353, 1819-23.

VOGELMEIER, C., HEDERER, B., GLAAB, T., SCHMIDT, H., RUTTEN-VAN MOLKEN, M. P., BEEH, K. M., RABE, K. F. & FABBRI, L. M. (2011) Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med, 364, 1093-1103.

VONBANK, K., ZIESCHE, R., HIGENBOTTAM, T. W., STIEBELLEHNER, L., PETKOV, V., SCHENK, P., GERMANN, P. & BLOCK, L. H. (2003) Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax, 58, 289-93.

WAGNER, E. H., AUSTIN, B. T. & VON KORFF, M. (1996) Organizing care for patients with chronic illness. Milbank Q, 74, 511-44.

WAKABAYASHI, K., GONZALEZ, M. A., DELHAYE, C., BEN-DOR, I., MALUENDA, G., COLLINS, S. D., SYED, A. I., GAGLIA, M. A., JR., TORGUSON, R., XUE, Z., SUDDATH, W. O., SATLER, L. F., KENT, K. M., LINDSAY, J., PICHARD, A. D. & WAKSMAN, R. (2010) Impact of chronic obstructive pulmonary disease on acute-phase outcome of myocardial infarction. Am J Cardiol, 106, 305-9.

WALSH, E. E., FALSEY, A. R. & HENNESSEY, P. A. (1999) Respiratory syncytial and other virus infections in persons with chronic cardiopulmonary disease. Am J Respir Crit Care Med, 160, 791-5.

WALTERS, J. A., GIBSON, P. G., WOOD-BAKER, R., HANNAY, M. & WALTERS, E. H. (2009) Systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD001288.

WALTERS, J. A., SMITH, S., POOLE, P., GRANGER, R. H. & WOOD-BAKER, R. (2011) Injectable vaccines for preventing pneumococcal infection in patients with chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD001390.

WALTERS, J. A., TURNOCK, A. C., WALTERS, E. H. & WOOD-BAKER, R. (2010) Action plans with limited patient education only for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD005074.

WALTERS, J. A., WANG, W., MORLEY, C., SOLTANI, A. & WOOD-BAKER, R. (2011c) Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD006897.

WEDZICHA, J. A., CALVERLEY, P. M., SEEMUNGAL, T. A., HAGAN, G., ANSARI, Z. & STOCKLEY, R. A. (2008) The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med, 177, 19-26.

WEEKES, C. E., EMERY, P. W. & ELIA, M. (2009) Dietary counselling and food fortification in stable COPD: a randomised trial. Thorax, 64, 326-31.

WEISBERG, J., WANGER, J., OLSON, J., STREIT, B., FOGARTY, C., MARTIN, T. & CASABURI, R. (2002) Megestrol acetate stimulates weight gain and ventilation in underweight COPD patients. Chest, 121, 1070-8.

WEITZENBLUM, E., SAUTEGEAU, A., EHRHART, M., MAMMOSSER, M. & PELLETIER, A. (1985) Long-term oxygen therapy can reverse the progression of pulmonary hypertension in patients with chronic obstructive pulmonary disease. Am Rev Respir Dis, 131, 493-8.

WELSH, E. J., CATES, C. J. & POOLE, P. (2010) Combination inhaled steroid and long-acting beta2-agonist versus tiotropium for chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD007891.

WELTE, T., MIRAVITLLES, M., HERNANDEZ, P., ERIKSSON, G., PETERSON, S., POLANOWSKI, T. & KESSLER, R. (2009) Efficacy and tolerability of budesonide/formoterol added to tiotropium in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 180, 741-50.

WIJKSTRA, P. J., TEN VERGERT, E. M., VAN ALTENA, R., OTTEN, V., KRAAN, J., POSTMA, D. S. & KOETER, G. H. (1995) Long term benefits of rehabilitation at home on quality of life and exercise tolerance in patients with chronic obstructive pulmonary disease. Thorax, 50, 824-8.

WIJKSTRA, P. J., VAN ALTENA, R., KRAAN, J., OTTEN, V., POSTMA, D. S. & KOETER, G. H. (1994) Quality of life in patients with chronic obstructive pulmonary disease improves after rehabilitation at home. Eur Respir J, 7, 269-73.

WILDMAN, M. J., SANDERSON, C. F., GROVES, J., REEVES, B. C., AYRES, J. G., HARRISON, D., YOUNG, D. & ROWAN, K. (2009) Survival and quality of life for patients with COPD or asthma admitted to intensive care in a UK multicentre cohort: the COPD and Asthma Outcome Study (CAOS). Thorax, 64, 128-32.

WILKINSON, T. M., DONALDSON, G. C., HURST, J. R., SEEMUNGAL, T. A. & WEDZICHA, J. A. (2004) Early therapy improves outcomes of exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 169, 1298-303.

WILLIAMS, J. H., JR. & MOSER, K. M. (1986) Pneumococcal vaccine and patients with chronic lung disease. Ann Intern Med, 104, 106-9.

WILSON, D. H., WAKEFIELD, M. A., STEVEN, I. D., ROHRSHEIM, R. A., ESTERMAN, A. J. & GRAHAM, N. M. (1990) "Sick of Smoking": evaluation of a targeted minimal smoking cessation intervention in general practice. Med J Aust, 152, 518-21.

WILSON, R. (1998) The role of infection in COPD. Chest, 113, 242S-248S.

WILT, T. J., NIEWOEHNER, D., KIM, C., KANE, R. L., LINABERY, A., TACKLIND, J., MACDONALD, R. & RUTKS, I. (2005) Use of spirometry for case finding, diagnosis, and management of chronic obstructive pulmonary disease (COPD). Evid Rep Technol Assess (Summ), 1-7.

WORLD HEALTH ORGANIZATION (1999) Tobacco Free Initiative: Policies for Public Health. Geneva, World Health Organization.

WOUTERS, E. F., POSTMA, D. S., FOKKENS, B., HOP, W. C., PRINS, J., KUIPERS, A. F., PASMA, H. R., HENSING, C. A. & CREUTZBERG, E. C. (2005) Withdrawal of fluticasone propionate from combined salmeterol/fluticasone treatment in patients with COPD causes immediate and sustained disease deterioration: a randomised controlled trial. Thorax, 60, 480-7.

XU, W., COLLET, J. P., SHAPIRO, S., LIN, Y., YANG, T., PLATT, R. W., WANG, C. & BOURBEAU, J. (2008) Independent effect of depression and anxiety on chronic obstructive pulmonary disease exacerbations and hospitalizations. Am J Respir Crit Care Med, 178, 913-20.

YANG, I. A., FONG, K. M., SIM, E. H., BLACK, P. N. & LASSERSON, T. J. (2007) Inhaled corticosteroids for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev, CD002991.

YEH, S. S., DEGUZMAN, B. & KRAMER, T. (2002) Reversal of COPD-associated weight loss using the anabolic agent oxandrolone. Chest, 122, 421-8.

YELLOWLEES, P. M., ALPERS, J. H., BOWDEN, J. J., BRYANT, G. D. & RUFFIN, R. E. (1987) Psychiatric morbidity in patients with chronic airflow obstruction. Med J Aust, 146, 305-7.

YOHANNES, A. M., WILLGOSS, T. G. & VESTBO, J. (2011) Tiotropium for treatment of stable COPD: a meta-analysis of clinically relevant outcomes. Respir Care, 56, 477-87.

YOUNG, I. H., CROCKETT, A. J. & MCDONALD, C. F. (1998) Adult domiciliary oxygen therapy. Position statement of the Thoracic Society of Australia and New Zealand. Med J Aust, 168, 21-5.

ZHENG, J. P., KANG, J., HUANG, S. G., CHEN, P., YAO, W. Z., YANG, L., BAI, C. X., WANG, C. Z., WANG, C., CHEN, B. Y., SHI, Y., LIU, C. T., CHEN, P., LI, Q., WANG, Z. S., HUANG, Y. J., LUO, Z. Y., CHEN, F. P., YUAN, J. Z., YUAN, B. T., QIAN, H. P., ZHI, R. C. & ZHONG, N. S. (2008) Effect of carbocisteine on acute exacerbation of chronic obstructive pulmonary disease (PEACE Study): a randomised placebo-controlled study. Lancet, 371, 2013-8.

ZHOU, Y., WANG, X., ZENG, X., QIU, R., XIE, J., LIU, S., ZHENG, J., ZHONG, N. & RAN, P. (2006) Positive benefits of theophylline in a randomized, double-blind, parallel-group, placebo-controlled study of low-dose, slow-release theophylline in the treatment of COPD for 1 year. Respirology, 11, 603-10.

ZWAR, N. A., MARKS, G. B., HERMIZ, O., MIDDLETON, S., COMINO, E. J., HASAN, I., VAGHOLKAR, S. & WILSON, S. F. (2011) Predictors of accuracy of diagnosis of chronic obstructive pulmonary disease in general practice. Med J Aust, 195, 168-71.